Colorectal cancer is the term used to describe cancer of the colon and/or rectum. The two cancers are grouped together because they share many common characteristics. Together, the colon and rectum make up the large intestine, a question mark-shaped bowel four feet in length. Colon cancer develops in all but the last few inches of the large intestine, between the appendix and rectum. Rectal cancer develops in the rectum, the last few inches of the large intestine that attaches to the anus. Colon cancer is more common. An estimated 95,000 new cases of colon cancer are diagnosed each year, compared to 39,000 cases of rectal cancer, according to the American Cancer Society.
Colorectal cancer may develop when benign polyps in the large intestine grow and become cancerous. There may be benign polyps or colorectal cancer in its earliest stages. As the cancer grows, symptoms may include abdominal pain or cramps; constipation or diarrhea; blood in the stool; bloating or a sense of not feeling empty after a bowel movement; flattened or ribbon-shaped stool and/or pain in the rectum. Signs of advanced colorectal cancer may include unexplained weight loss, fatigue, anemia and loss of appetite.
The risk factors for colorectal cancer may be reduced with regular checkups and lifestyle changes. The American Cancer Society recommends that most men and women of average risk have a colonoscopy beginning at age 45. If you have a family history of colorectal cancer, you should get screened 10 years earlier than when your family member was diagnosed.
According to the Centers for Disease Control and Prevention, 1-in-3 screening eligible adults do not get screened. Why do so many people avoid getting screened? There are many reasons, including:
- Lack of insurance coverage
- Fears about the test or colonoscopy preparation
- Their primary care doctor hasn’t suggested it
- They’re too busy or don’t think they have the time
- Cultural and/or socioeconomic reasons
- Failure to understand the risks associated with not being screened
Yes, it is possible to have blood in your stool but not have colon cancer. Hemorrhoids, anal fissures or tears, infections of the colon (infectious diarrhea), inflammatory bowel disease (ulcerative colitis or Crohn's colitis), colonic diverticula and abnormal blood vessels (arteriovenous malformations or angiodysplasia) may all be associated with bleeding from the rectum or colon. Blood in the stool may also occur from lesions in the stomach and small intestine such as peptic ulcer disease, angiodysplasia and Crohn's disease of the small intestine. Rectal bleeding of any amount of blood in or on the stool is never normal and should not be ignored, as some causes are more serious than others.
2. Stool-Fecal DNA tests
3. BeScreened – CRC Blood Test
4. Computed tomography (CT or CAT) colonography
6. Fecal occult blood test (FOBT) and fecal immunochemical test (FIT)
7. Methylated Septin 9 test
BeScreened-CRC is 94.6% accurate at determining the likely presence or absence of CRC.
BeScreened-CRC is as a simple blood-based test that aides in the detection of colorectal cancer. If you are:
50-years of age and older
Considered to be at average-risk
Have been unwilling or unable to participate in CRC screening using existing fecal-based testing and invasive imaging procedures, such as colonoscopies
BeScreened-CRC was developed specifically for you. No stool sample, bowel prep or time off work.
A positive result can indicate the presence of colorectal cancer (CRC) or advanced adenoma (pre-cancer). While BeScreened-CRC is a highly accurate test, it may also produce a positive result even though a colonoscopy may not find colorectal cancer or precancerous polyps. Such a result is called a “False Positive” . It’s important to note that all screening tests have false positives regardless of whose test it is.
As such, it is recommended that further clinical evaluation take place and that a follow-up investigation with a structural examination of the colon such as a screening colonoscopy be conducted.
A negative result indicates a lower likelihood that colorectal cancer (CRC) or advanced adenoma (pre- cancer) is present. While BeScreened-CRC is a highly accurate test, a negative test result does not guarantee the absence of colorectal cancer or advanced adenoma (pre-cancer). Patients with a negative Be-Screened result are advised to participate in a colorectal cancer screening program and do so at a recommended interval and with a method appropriate for the patient and their personal medical history.
BeScreened-CRC is intended for colorectal cancer screening of adults regardless of gender, 50 years or older, who are at typical average-risk for colorectal cancer and who are unable or unwilling to undergo other colorectal cancer screening methods.
BeScreened-CRC is a blood-based test that tests for three tumor associated proteins and then analyzes those results using a proprietary relational algorithm to determine the patient’s CRC risk profile as to the lower (negative) or higher (positive) likelihood that colorectal cancer (CRC) or advanced adenoma (pre- cancer) is present. Its performance has been established by Beacon Biomedical in a cross-sectional study in patients of both sexes, 50 years or older, who are at a typical average-risk for colorectal cancer.
As a laboratory developed test (LDT) under the Centers for Medicare and Medicaid Services’ (CMS’) Clinical Laboratory Improvement Amendments (CLIA), BeScreened-CRC is available for clinical use and it does not require FDA clearance or approval. BeScreened-CRC was developed exclusively by Beacon Biomedical, Inc. Beacon is certified under CLIA to perform high complexity clinical laboratory testing and is accredited to offer BeScreened-CRC to the public as a CRC screening test. This test is intended as a CRC screening test and is not to be regarded as being investigational or for research.